I would start out by drawing the movements in an Illustrator document, I had to give a lot of thought to the timing and which movements she would hold on, and which she would move through quickly. I had to make sure there were an adequate amount of frame drawings for smoother movement, else things could look quite "jumpy".
Next, I took the drawings into Photoshop and filled them with her texture. In drawings with a lot of movement, such as this one, I had to use reference points within the drawing and texture to keep Flo's filling consistent in each frame.
Finally, I selected the drawings one by one and placed them in their scene, which was often in Photoshop. I aligned them, and in timeline view, set the layers to appear at their appropriate pacing. Depending on the complexity of the scene, I could also make the waves bob and have it completed within Photoshop. However if keyframing was needed, I would take the scene into After Effects and complete the scene there.
Here is the finished product!